An article published this year in “NANOMEDICINE” using our Peptide Production
Service,
by our customers from Immunology Division, Germans Trias i Pujol University
Hospital & Research Institute, Department of Cellular Biology, Physiology
& Immunology, Autonomous University of Barcelona, Badalona, Spain, in the
analysis Liposome-based immunotherapy against autoimmune diseases: therapeutic
effect on multiple sclerosis. Congrats and Thanks.
Summary:
Aim: Based on the ability of
apoptosis to induce immunological tolerance, liposomes were generated mimicking
apoptotic cells, and they arrest autoimmunity in Type 1 diabetes. Our aim was
to validate the immunotherapy in other autoimmune disease: multiple sclerosis.
Materials & methods: Phosphatidylserine-rich liposomes were loaded with
disease-specific autoantigen. Therapeutic capability of liposomes was assessed
in vitro and in vivo. Results: Liposomes induced a tolerogenic phenotype in
dendritic cells, and arrested autoimmunity, thus decreasing the incidence,
delaying the onset and reducing the severity of experimental disease,
correlating with an increase in a probably regulatory CD25+ FoxP3- CD4+ T-cell
subset. Conclusion: This is the first work that confirms
phosphatidylserine-liposomes as a powerful tool to arrest multiple sclerosis,
demonstrating its relevance for clinical application.
Reference:
Product link:
Peptide production Service: http://www.immunostep.com/content/25-peptide-production
No comments:
Post a Comment