An article published this year in “Journal of Colloid and Interface Science” using one of our products, “FITC Apoptosis Detection Kit”, by our customers from the University of Zaragoza, Spain, in the analysis of how Controlled release of bupivacaine using hybrid thermoresponsive nanoparticles activated via photothermal heating. Congrats and Thanks.
Summay:
Near-infrared (NIR) responsive nanoparticles are of great
interest in the biomedical field as antennas for photothermal therapy and also
as triggers for on-demand drug delivery. The present work reports the
preparation of hollow gold nanoparticles (HGNPs) with plasmonic absorption in
the NIR region covalently bound to a thermoresponsive polymeric shell that can
be used as an on-demand drug delivery system for the release of analgesic drugs. The photothermal
heating induced by the nanoparticles is able to produce the collapse of the
polymeric shell thus generating the release of the local anesthetic bupivacaine in a spatiotemporally controlled way. Those HGNPs contain a
10 wt.% of polymer and present excellent reversible heating under NIR light
excitation. Bupivacaine released at physiological temperature (37 °C) showed a
pseudo-zero order release that could be spatiotemporally modified on-demand
after applying several pulses of light/temperature above and below the lower critical solution temperature (LCST) of the polymeric shell. Furthermore, the nanomaterials obtained did not displayed detrimental effects on four mammalian cell lines at doses
up to 0.2 mg/mL. From the results obtained it can be concluded than this type
of hybrid thermoresponsive nanoparticle can be used as an externally activated
on-demand drug delivery system.
Reference:
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