An article published this year in “IEEExplore Digital Library” using one of our products, “Propidium Iodide”, by our customers from Department of Advanced Energy, the University of Tokyo, Kashiwanoha, Kashiwa, Chiba, Japan., in the analysis of how Genotoxicity of tetrahydrofolic acid to hematopoietic stem and progenitor cells. Congrats and Thanks.
Summay:
Plasma irradiation of cancer is
expected to activate a cancer-specific immune response; however, its long-term
systemic effect in animal models has not been sufficiently investigated. In
this study, the long-term systemic effect induced by plasma irradiation was
examined using C57BL/6 mice inoculated with B16F10 melanoma. Melanoma tumors on
the right hind legs of the mice were resected after treatment with nanosecond
pulsed streamer discharge. The results showed that plasma treatment delayed the
growth of recurrent tumors at the site of resection. In addition, plasma
treatment delayed the growth of tumors re-inoculated at the non-irradiated site
on the left leg of the mice after resection. Histological and single-cell
analyses revealed that plasma had no direct effect on primary tumors, whereas
it enhanced cytotoxic T cell infiltration into re-inoculated tumors. These
results suggest that plasma treatment induces cancer-specific long-term immune
memory in mice.
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