An article published this year in “Revista Española de Patología torácica” using some of our products, “CF-Blue AnnexinV”, by our customers present at the IBIS Research Center, Sevilla, Spain in the analysis of CELULAR ORIGIN OF CIRCULATING MICROPARTICLES IN PATIENTS WITH VENOUS THROMBOEMBOLISM AND CANCER. Congrats and Thanks.
Summay:
Micro particles (MPs) are
extracellular vesicles considered to be powerful cellular effectors. They are
present in healthy individuals and are elevated in pathological conditions such
as inflammatory and neoplastic diseases, and thrombosis. The relationship
between venous thromboembolism (VTE) and cancer has been well established. MPs
are thought to be a pathogenic connection between the two entities. If
confirmed, they could be used as biomarkers. Our aim was to characterize the
MPs in both diseases according to their cellular origin (cellular, endothelial,
platelet, leukocyte and those that exhibited mucin 1 on their surface).
Functional parameters such as D-dimer (DD) and soluble P-selectin (sPsel) were
also studied. 96 patients with idiopathic VTE and 85 with advanced lung,
stomach or pancreatic neoplasia were considered. All of them were followed
clinically for two years and those who were diagnosed with cancer in the VTE
group or those who developed thrombosis in the group of neoplastic patients
were excluded from the study. Finally, 82 VTE patients and 68 cancer patients
were analyzed.
In our results, we found that
total MPs and platelet-derived MPs differentiated both patient groups.
Additionally, significantly greater numbers of DD and sPsel (p<0.001)
were determined in the VTE group. The differences found between both groups,
taking into account the origin of the MPs, could be caused by the prothrombotic
characteristics of the neoplastic group and their sequestration within active
clots in the VTE group
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