An article published this year in “Plos One” using some of our products, “FITC Apoptosis Detection Kit”, by our customers present at the Institute of Health Research & Hospital Lozano Blesa from Zaragoza as well as University and Hospital San Jorge from Huesca, Spain, in the analysis of Pharmacological activation of TRPV4 produces immediate cell damage and induction of apoptosis in human melanoma cells and HaCaT keratinocytes. Congrats and Thanks.
Summay:
TRPV4
channels are calcium-permeable cation channels that are activated by several
physicochemical stimuli. Accordingly, TRPV4 channels have been implicated in
the regulation of osmosensing, mechanotransduction, thermosensation, and
epithelial/endothelial barrier functions. Whether TRPV4 is also mechanistically
implicated in melanoma cell proliferation is not clear. Here, we hypothesized
that TRPV4 is expressed in human melanoma and that pharmacological activation
interferes with cell proliferation.
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