An article published this year in “Plos One” using some of our products, “FITC Apoptosis Detection Kit”, by our customers present at the Institute of Health Research & Hospital Lozano Blesa from Zaragoza as well as University and Hospital San Jorge from Huesca, Spain, in the analysis of Pharmacological activation of TRPV4 produces immediate cell damage and induction of apoptosis in human melanoma cells and HaCaT keratinocytes. Congrats and Thanks.
TRPV4 channels are calcium-permeable cation channels that are activated by several physicochemical stimuli. Accordingly, TRPV4 channels have been implicated in the regulation of osmosensing, mechanotransduction, thermosensation, and epithelial/endothelial barrier functions. Whether TRPV4 is also mechanistically implicated in melanoma cell proliferation is not clear. Here, we hypothesized that TRPV4 is expressed in human melanoma and that pharmacological activation interferes with cell proliferation.