An article published in “Nature Comunications” using our some of our mouse antibodies such us Biotin Anti-Mouse CD4 (clone GK1.5), Biotin Anti-Mouse IgM and Biotin Anti-Mouse CD16/32 (clone 2.4G2) by our customers from Spanish National Center of Biotechnology, Madrid, Spain, in the analysis of how Conventional CD4+ T cells present bacterial antigens to induce cytotoxic and memory CD8+ T cell responses. Congrats and Thanks.
Summary:
Bacterial
phagocytosis and antigen cross-presentation to activate CD8+T cells are principal functions of professional antigen
presenting cells. However, conventional CD4+ T cells also
capture and kill bacteria from infected dendritic cells in a process termed
transphagocytosis (also known as transinfection). Here, we show that
transphagocytic T cells present bacterial antigens to naive CD8+ T cells, which proliferate and become cytotoxic in
response. CD4+ T-cell-mediated
antigen presentation also occurs in vivo in the course of infection, and
induces the generation of central memory CD8+ T cells with low PD-1 expression. Moreover,
transphagocytic CD4+ T cells
induce protective anti-tumour immune responses by priming CD8+ T cells, highlighting the potential of CD4+ T cells as a tool for cancer immunotherapy.
Reference:
Products link:
Biotin Anti-Mouse CD4
(clone GK1.5),
Biotin Anti-Mouse
CD16/32 (clone 2.4G2)
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