An article published this year in “JOURNAL OF MATERIALS CHEMISTRY B”
using our Annexin V-FITC
Apoptosis Detection Kit, by our customers from Institut Lavoisier, UMR 8180 CNRS Universite´ de
Versailles Saint-Quentin-en-Yvelines, Versailles, France, in the study of how
Crystal structure dependent in vitro antioxidant activity of biocompatible
calcium gallate MOFs. Congrats and Thanks.
Summary:
Two novel 3-D coordination polymers, denoted MIL-155 and MIL-156 (MIL stands
for Materials Institute Lavoisier), built up from calcium and the naturally
occurring gallic acid (H4gal), have been hydrothermally synthesized and their
crystal structures were determined by single-crystal X-ray diffraction. These
solids are based on different inorganic subunits: infinite chains of
edge-sharing dimers of CaO7 polyhedra linked through partially deprotonated
gallate ligands (H2gal2_) for MIL-155 or [Ca2(H2O)(H2gal)2]_2H2O, and ribbon-like
inorganic subunits containing both eight-fold or six-fold coordinated CaII ions
linked through fully deprotonated gallate ligands (gal4_) for MIL-156 or
[Ca3K2(H2O)2(gal)2]_nH2O (n B 5). Both solids contain small channels filled
with water molecules, with, however no accessible porosity towards N2 at 77 K.
MIL-155 and MIL-156 were proven to be biocompatible, as evidenced by in vitro
assays (viability and cell proliferation/death balance). While the high
chemical stability of MIL-156 makes it almost bioinert, the progressive
degradation of MIL-155 leads to an important protective antioxidant effect, associated
with the release of the bioactive gallate ligand.
Reference:
Product link:
FITC Annexin V Apoptosis Detection Kit: http://www.immunostep.com/apoptosis-tools/3741-anxvkf-100t.html
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