Friday 29 December 2017

An article published in “Neumosur.net” using our “CF-Blue Apoptosis Detection Kit” by our customers from the Center for Biomedical Research in Respiratory Diseases Network (CIBERES), Hospital Universitario Virgen del Rocío de Sevilla, Spain, in the analysis of CELLULAR ORIGIN OF CIRCULATING MICRO-PARTICLES IN PATIENTS WITH VENOUS THROMBOEMBOLIC DISEASE AND CANCER. Congrats and Thanks.


Summary:
Microparticles (MPs) are extracellular vesicles considered to be powerful cellular effectors. They are present in healthy individuals and are elevated in disease states such as diseases inflammatory, neoplastic and thrombosis. The relationship between venous thromboembolic disease (VTE) and cancer is well established It is thought that MPs would be a pathogenic connection between both entities. If confirmed, they could be used as biomarkers.
Our objective was to characterize the MPs in both pathologies according to their cellular origin (cellular, endothelial, platelet, leukocyte and those that exhibited mucin on its surface 1). Functional parameters were also studied such as dimer D (DD) and soluble P-selectin (sPS).
We considered 96 patients with idiopathic VTE and 85 with advanced neoplasms of lung, gastric or pancreas. To all of them underwent a clinical follow-up of two years in which those who were excluded from the study were excluded diagnosed with cancer in the ETV group or who developed thrombosis in the group of neoplastic patients. Finally, 82 patients with VTE and 68 with cancer were analyzed.
In our results we found that the total MPs and the MPs of platelet origin differentiated both groups of patients. In addition, significantly higher numbers of DD and sPS were determined (p <0.001) in the group of ETV. The differences found between both groups, taking into account the origin of the MPs, could be caused by the prothrombotic characteristics of the neoplastic group and the sequestration thereof within the clots assets in the ETV group.

Reference:

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CF-Blue Apoptosis Detection Kit

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