An article published in “Neumosur.net” using our “CF-Blue Apoptosis Detection Kit” by our customers from the Center for Biomedical Research in Respiratory Diseases Network (CIBERES), Hospital Universitario Virgen del Rocío de Sevilla, Spain, in the analysis of CELLULAR ORIGIN OF CIRCULATING MICRO-PARTICLES IN PATIENTS WITH VENOUS THROMBOEMBOLIC DISEASE AND CANCER. Congrats and Thanks.
Summary:
Microparticles
(MPs) are extracellular vesicles considered to be powerful cellular effectors. They
are present in healthy individuals and are elevated in disease states such as
diseases inflammatory, neoplastic and thrombosis. The relationship between
venous thromboembolic disease (VTE) and cancer is well established It is
thought that MPs would be a pathogenic connection between both entities. If
confirmed, they could be used as biomarkers.
Our
objective was to characterize the MPs in both pathologies according to their
cellular origin (cellular, endothelial, platelet, leukocyte and those that
exhibited mucin on its surface 1). Functional parameters were also studied such
as dimer D (DD) and soluble P-selectin (sPS).
We
considered 96 patients with idiopathic VTE and 85 with advanced neoplasms of
lung, gastric or pancreas. To all of them underwent a clinical follow-up of two
years in which those who were excluded from the study were excluded diagnosed
with cancer in the ETV group or who developed thrombosis in the group of neoplastic
patients. Finally, 82 patients with VTE and 68 with cancer were analyzed.
In
our results we found that the total MPs and the MPs of platelet origin
differentiated both groups of patients. In addition, significantly higher
numbers of DD and sPS were determined (p <0.001) in the group of ETV. The
differences found between both groups, taking into account the origin of the
MPs, could be caused by the prothrombotic characteristics of the neoplastic
group and the sequestration thereof within the clots assets in the ETV group.
Reference:
Products link:
CF-Blue Apoptosis
Detection Kit
No comments:
Post a Comment