An article published this year in
“JOURNAL OF THROMBOSIS AND THROMBOLYSIS” using our Kit for
Paroxysomal Nocturnal Hemoglobinuria (PNH), by our customers from
Hematology Laboratory (Division of Thrombosis and Hemostasis), ICO-Badalona,
Hospital Germans Trias i Pujol, Josep Carreras Leukemia Research
InstituteUniversitat Autonoma de Barcelona, Badalona, Spain, in the study of
Retinal vein occlusion and paroxysmal nocturnal hemoglobinuria. Congrats and
Thanks.
Summary:
Paroxysmal
nocturnal hemoglobinuria (PNH) is a rare disorder associated with increased
risk for thrombosis and reduced life expectancy. Retinal vein occlusion (RVO)
is a frequent cause of vision loss but its relationship with PNH has not been
studied systematically. Patients followed up for RVO in our ophthalmology
department were screened for the presence of a PNH clone in peripheral blood by
means of flow cytometry. The presence of other well-documented risk factors for
RVO was also analyzed. In a series of 110 patients (54 males, median age of 67)
we found no evidence of PNH. Most patients (97/110) had cardiovascular risk
factors and/or hyperhomocysteinemia (67/110). Inherited thrombophilias were
rare (three confirmed cases). Therefore, PNH does not appear to play a role in the
development of RVO. However, this finding does not necessarily apply to young
patients and/or those with no conventional risk factors for RVO, due to the low
number of patients in these subgroups in our population.
Reference:
Product link:
Kit for Paroxysomal
Nocturnal Hemoglobinuria (PNH): http://www.immunostep.com/diagnostic-kits/2335-pnh-kit.html
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